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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384565
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
52.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384565
Synonyms:
2-[(4-{[trans-4- (dimethylamino)cyclohexyl] amino}quinazolin-6- yl)oxy]acetamide | US9932350, 2-17
Type:
Small organic molecule
Emp. Form.:
C18H25N5O2
Mol. Mass.:
343.4234
SMILES:
CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(OCC(N)=O)cc12 |r,wU:3.2,wD:6.9,(2.31,-7.34,;3.08,-6,;4.62,-6,;2.31,-4.67,;.77,-4.67,;,-3.33,;.77,-2,;2.31,-2,;3.08,-3.33,;,-.67,;-1.54,-.67,;-2.31,-2,;-3.85,-2,;-4.62,-.67,;-3.85,.67,;-4.62,2,;-3.85,3.33,;-2.31,3.33,;-1.54,4.67,;,4.67,;.77,6,;2.31,6,;,7.34,;-1.54,2,;-2.31,.67,)|
Structure:
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