Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384584
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
114±n/a nM
Citation
 Altman, MDBrubaker, JDChilders, MLDonofrio, AFischmann, TGibeau, CRKattar, SDLesburg, CALim, JMaclean, JKMansoor, UFNorthrup, ABSanders, JMSmith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384584
Synonyms:
4-({trans-4-[(1S,4S)-2- oxa-5- azabicyclo[2.2.1]hept-5- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-18
Type:
Small organic molecule
Emp. Form.:
C20H23N5O
Mol. Mass.:
349.4295
SMILES:
N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3C[C@@H]4C[C@H]3CO4)c2c1 |r,wU:14.17,21.21,19.20,wD:11.10,(-1.15,8,;-1.93,6.67,;-2.69,5.33,;-4.23,5.33,;-5,4,;-4.23,2.67,;-5,1.33,;-4.23,,;-2.69,,;-1.93,1.33,;-.38,1.33,;.38,,;-.38,-1.33,;.38,-2.67,;1.93,-2.67,;2.69,-1.33,;1.93,,;2.69,-4,;1.93,-5.33,;2.69,-6.67,;3.96,-5.62,;4.23,-4,;5,-5.33,;4.23,-6.67,;-2.69,2.67,;-1.93,4,)|
Structure:
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