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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384611
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
5.00±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384611
Synonyms:
4-({trans-4-[(3R or 3S)- 3-(morpholin-4- ylmethyl)piperidin-1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-41 | US9932350, 3-42
Type:
Small organic molecule
Emp. Form.:
C25H34N6O
Mol. Mass.:
434.5771
SMILES:
N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCCC(CN4CCOCC4)C3)c2c1 |r,wU:14.17,wD:11.10,(-1.15,10,;-1.93,8.67,;-2.69,7.34,;-4.23,7.34,;-5,6,;-4.23,4.67,;-5,3.33,;-4.23,2,;-2.69,2,;-1.93,3.33,;-.38,3.33,;.38,2,;-.38,.67,;.38,-.67,;1.93,-.67,;2.69,.67,;1.93,2,;2.69,-2,;4.23,-2,;5,-3.33,;4.23,-4.67,;2.69,-4.67,;1.93,-6,;2.69,-7.34,;1.93,-8.67,;2.69,-10,;4.23,-10,;5,-8.67,;4.23,-7.34,;1.93,-3.33,;-2.69,4.67,;-1.93,6,)|
Structure:
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