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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384620
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
579±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384620
Synonyms:
4-({trans-4-[(1R,5S)-8- oxa-3- azabicylco[3.2.1]oct-3- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-50
Type:
Small organic molecule
Emp. Form.:
C21H25N5O
Mol. Mass.:
363.4561
SMILES:
N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3C[C@@H]4CC[C@H](C3)O4)c2c1 |r,wU:14.17,22.22,wD:11.10,19.26,(-1.82,8,;-2.59,6.67,;-3.36,5.33,;-4.9,5.33,;-5.67,4,;-4.9,2.67,;-5.67,1.33,;-4.9,,;-3.36,,;-2.59,1.33,;-1.05,1.33,;-.28,,;-1.05,-1.33,;-.28,-2.67,;1.26,-2.67,;2.03,-1.33,;1.26,,;2.03,-4,;1.26,-5.33,;2.03,-6.67,;2.8,-8,;5.11,-6.67,;4.34,-5.33,;3.57,-4,;3.57,-6.67,;-3.36,2.67,;-2.59,4,)|
Structure:
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