Reaction Details Report a problem with these data
Target
Proto-oncogene Wnt-1
Ligand
BDBM384771
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
EC50
>10000±n/a nM
Citation
 KC, SK; Wallace, DM; Cao, J; Chiruta, C; Hood, J 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof US Patent  US10285983 Publication Date 5/14/2019 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM384771
Synonyms:
US10285983, Compound 271
Type:
Small organic molecule
Emp. Form.:
C23H21N7O
Mol. Mass.:
411.4591
SMILES:
CCCCC(=O)Nc1cncc(c1)-c1cnc2[nH]nc(-c3cc4cccnc4[nH]3)c2c1
Structure:
Search PDB for entries with ligand similarity: