Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM309438
Substrate
n/a
Meas. Tech.
Opioid Receptor Binding Assay
IC50
18.0±n/a nM
Citation
 Blumberg, LC; Deaver, DR; Eyerman, DJ; Wynn, TA Morphan and morphinan analogues, and methods of use US Patent  US10287250 Publication Date 5/14/2019 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM309438
Synonyms:
US10287250, Compound C.8 | US9656961, Example 00158
Type:
Small organic molecule
Emp. Form.:
C30H36N4O
Mol. Mass.:
468.633
SMILES:
CC1[C@H]2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)C(=O)NCCc1ccc(cc1)-c1cn[nH]c1 |r,TLB:15:14:9.4.3:1|
Structure:
Search PDB for entries with ligand similarity: