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Target
Proto-oncogene Wnt-1
Ligand
BDBM385167
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
EC50
258±n/a nM
Citation
 KC, SK; Mittapalli, GK; Hofilena, BJ; Marakovits, JT; Chiruta, C; Mak, CC; Cao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent  US10287267 Publication Date 5/14/2019 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM385167
Synonyms:
US10287267, Compound 327 | US10508099, Compound 1081 | US10556885, Compound 1081 | US10604514, Compound 145 | US11174244, Compound 1081 | US11673881, Compound 1081
Type:
Small organic molecule
Emp. Form.:
C22H27N5O
Mol. Mass.:
377.4827
SMILES:
CN(C)[C@H]1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |r,wU:3.2,(9.19,1.16,;7.85,1.93,;7.85,3.47,;6.52,1.15,;6.52,-.39,;5.19,-1.15,;3.85,-.39,;3.85,1.15,;5.19,1.92,;2.52,-1.16,;2.52,-2.7,;1.18,-.39,;-.15,-1.16,;-1.48,-.39,;-2.82,-1.16,;-4.15,-.39,;-5.48,-1.16,;-5.48,-2.7,;-4.15,-3.47,;-2.82,-2.7,;-1.48,-3.47,;-.15,-2.7,;-6.82,-.39,;-8.28,-.86,;-9.19,.38,;-8.28,1.63,;-9.05,2.96,;-6.82,1.15,)|
Structure:
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