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TargetGlycogen synthase kinase-3 beta
LigandBDBM385115
Substrate/Competitorn/a
Meas. Tech.The screening for GSK3beta kinase activity
EC50 3.00±n/a nM
Citation KC, SKMittapalli, GKHofilena, BJMarakovits, JTChiruta, CMak, CCCao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10287267 Publication Date 5/14/2019
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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  Blast E-value cutoff:
BDBM385115
NameBDBM385115
Synonyms:US10287267, Compound 271 | US10508099, Compound 271 | US10556885, Compound 271
TypeSmall organic molecule
Emp. Form.C21H23F3N6O
Mol. Mass.432.4421
SMILESCn1cc(nn1)-c1ccc2cnc(NC(=O)C3CCN(CCC(F)(F)F)CC3)cc2c1
Structure
n/a