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Target
Oxysterols receptor LXR-beta [154-461]
Ligand
BDBM20001
Substrate
BDBM19993
Meas. Tech.
LXR Binding Assay and hLXR Reporter Assay
pH
7.4±n/a
Temperature
277.15±n/a K
IC50
2±n/a nM
EC50
90±n/a nM
Comments
70% efficacy.
Citation
 Wrobel, J; Steffan†, R; Bowen, SM; Magolda, R; Matelan†, E; Unwalla†, R; Basso, M; Clerin, V; Gardell, SJ; Nambi, P; Quinet, E; Reminick, JI; Vlasuk, GP; Wang, S; Feingold, I; Huselton, C; Bonn, T Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride Synthesis J Med Chem 51:7161-8 (2008) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta [154-461]
Synonyms:
LXRB | Liver X Receptor beta (LXR-beta) | NER | NR1H2 | NR1H2_HUMAN | Nuclear orphan receptor LXR-beta | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | UNR | Ubiquitously-expressed nuclear receptor
Type:
Receptor
Mol. Mass.:
34695.52
Organism:
Homo sapiens (Human)
Description:
LXR beta ligand binding domain (amino acid residues 154-461) with an N-terminal biotinylation tag expressed in E.coli, was used for the binding assays.
Residue:
308
Sequence:
MREQCVLSEEQIRKKKIRKQQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH
  
Inhibitor
Name:
BDBM20001
Synonyms:
2-{4-[({3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid | BMC153321 Compound 4 | JMC517161 Compound 4 | Quinoline 16
Type:
Small organic molecule
Emp. Form.:
C32H25F3N2O2
Mol. Mass.:
526.5483
SMILES:
OC(=O)Cc1ccc(CNc2cccc(c2)-c2c(Cc3ccccc3)cnc3c(cccc23)C(F)(F)F)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19993
Synonyms:
CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T 0901317 | T0901317 | TO-901317 | US10543183, Compound TO901317 | US10669296, Compound TO901317 | US10945978, Compound 1 | [3H]T0901317
Type:
Small organic molecule
Emp. Form.:
C17H12F9NO3S
Mol. Mass.:
481.333
SMILES:
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: