Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Epidermal growth factor receptor [696-1022,T790M]
Ligand
BDBM26105
Substrate
BDBM10852
Meas. Tech.
Fluorescence Binding Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Kd
27.6±.7 nM
Citation
Yun, CH; Mengwasser, KE; Toms, AV; Woo, MS; Greulich, H; Wong, KK; Meyerson, M; Eck, MJ The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A 105:2070-5 (2008) [PubMed] Article More Info.:
Target
Name:
Epidermal growth factor receptor [696-1022,T790M]
Synonyms:
EGF-R Tyrosine Kinase Mutant (T790M) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1
Type:
Tyrosine-protein kinase
Mol. Mass.:
37282.81
Organism:
Homo sapiens (Human)
Description:
P00533[696-1022,T790M]
Residue:
327
Sequence:
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG
Inhibitor
Name:
BDBM26105
Synonyms:
6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | AEE788
Type:
Small organic molecule
Emp. Form.:
C27H32N6
Mol. Mass.:
440.5832
SMILES:
CCN1CCN(Cc2ccc(cc2)-c2cc3c(N[C@H](C)c4ccccc4)ncnc3[nH]2)CC1 |r|
Structure:
Substrate