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Target
Monoglyceride lipase
Ligand
BDBM26126
Substrate
BDBM26144
Meas. Tech.
FAAH Inhibition Assay
IC50
71000±n/a nM
Citation
 Minkkilä, A; Saario, SM; Käsnänen, H; Leppänen, J; Poso, A; Nevalainen, T Discovery of Boronic Acids as Novel and Potent Inhibitors of Fatty Acid Amide Hydrolase. J Med Chem 51:7057-60 (2008) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM26126
Synonyms:
(3-phenylphenyl)boranediol | Phenylboronic Acid, 5
Type:
Small organic molecule
Emp. Form.:
C12H11BO2
Mol. Mass.:
198.026
SMILES:
OB(O)c1cccc(c1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM26144
Synonyms:
1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate | 2-Arachidonoylmonoglycerol (2-AG) | 2-arachidonoylglycerol (2-AG) | 2-arachidonyl-glycerol | CHEMBL122972
Type:
Endocannabinoids
Emp. Form.:
C23H38O4
Mol. Mass.:
378.5454
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC(CO)CO
Structure:
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