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Target
Nuclear receptor ROR-gamma
Ligand
BDBM385429
Substrate
n/a
Meas. Tech.
Biological Assay for RORgammaT Activity
IC50
6.00±n/a nM
Citation
 Lapointe, BT; Fuller, PH; Gunaydin, H; Liu, K; Scott, ME; Trotter, BW; Zhang, H Substituted indazole compounds as RORgammaT inhibitors and uses thereof US Patent  US10287272 Publication Date 5/14/2019 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM385429
Synonyms:
4-((R or S)-1-chloro- 6-cyclopropylbenzoyl)- 6-((S)-3- (dimethylamino) pyrrolidine-1-carbonyl)- 4,5,6,7-tetrahydro-1H- indazol-3-yl)cyclohex- 3-ene-1-carboxylic acid | US10287272, Example 2LL | US10689369, Example 2LL
Type:
Small organic molecule
Emp. Form.:
C31H37ClN4O4
Mol. Mass.:
565.103
SMILES:
CN(C)[C@H]1CCN(C1)C(=O)C1CCc2c(C1)n(nc2C1=CCC(CC1)C(O)=O)C(=O)c1c(Cl)cccc1C1CC1 |r,t:22|
Structure:
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