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Target
Nuclear receptor ROR-gamma
Ligand
BDBM385466
Substrate
n/a
Meas. Tech.
Biological Assay for RORgammaT Activity
IC50
65.0±n/a nM
Citation
 Lapointe, BT; Fuller, PH; Gunaydin, H; Liu, K; Scott, ME; Trotter, BW; Zhang, H Substituted indazole compounds as RORgammaT inhibitors and uses thereof US Patent  US10287272 Publication Date 5/14/2019 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM385466
Synonyms:
(R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoromethyl) cyclopropyl)benzoyl)-6- (((4-fluoropiperidin-4- yl)methyl)carbamoyl)- 4,5,6,7-tetrahydro-1H- indazol-3-yl)cyclohex-3- ene-1-carboxylic acid | US10287272, Example 5K | US10689369, Example 5K
Type:
Small organic molecule
Emp. Form.:
C32H35ClF4N4O4
Mol. Mass.:
651.091
SMILES:
OC(=O)C1CCC(=CC1)c1nn(C(=O)c2c(Cl)cccc2C2(CC2)C(F)(F)F)c2CC(CCc12)C(=O)NCC1(F)CCNCC1 |c:6|
Structure:
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