Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 1
Ligand
BDBM385548
Substrate
n/a
Meas. Tech.
In Vitro Affinity
IC50
>200±n/a nM
Citation
 Musicki, B; Bhurruth-Alcor, Y Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies US Patent  US10287278 Publication Date 5/14/2019 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM385548
Synonyms:
US10287278, Example 10 | US10647706, Example 10
Type:
Small organic molecule
Emp. Form.:
C20H29ClN4O4S
Mol. Mass.:
456.987
SMILES:
CCC(CC)Nc1c(Nc2ccc(Cl)c(c2O)S(C)(=O)=NCCN(C)C)c(=O)c1=O
Structure:
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