Target
Baculoviral IAP repeat-containing protein 3 [238-349]
Ligand
BDBM26206
Substrate
Smac-derived peptide
Meas. Tech.
Fluorescence Polarization Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
5.9±1.0 nM
Citation
 Zhang, BNikolovska-Coleska, ZZhang, YBai, LQiu, SYang, CYSun, HWang, SWu, Y Design, Synthesis, and Evaluation of Tricyclic, Conformationally Constrained Small-Molecule Mimetics of Second Mitochondria-Derived Activator of Caspases. J Med Chem 51:7352-5 (2008) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 3 [238-349]
Synonyms:
API2 | Apoptosis inhibitor 2 | BIRC3 | BIRC3_HUMAN | Baculoviral IAP repeat-containing protein 3 | HIAP-1 | Inhibitor of apoptosis protein 1 | MIHC | RNF49 | TNFR2-TRAF-signaling complex protein 1 | cIAP-2 BIR3
Type:
BIR3 domain
Mol. Mass.:
12945.93
Organism:
Homo sapiens (Human)
Description:
Human cIAP2 BIR3 domain (residues 238-349) was used in binding assays.
Residue:
112
Sequence:
QLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTS
  
Inhibitor
Name:
BDBM26206
Synonyms:
(2R,5S,8S)-N-(diphenylmethyl)-8-[(2S)-2-(methylamino)propanamido]-7-oxo-6-azatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),11,13-triene-5-carboxamide | Smac mimetic, 5
Type:
Small organic molecule
Emp. Form.:
C31H34N4O3
Mol. Mass.:
510.6267
SMILES:
CN[C@@H](C)C(=O)N[C@H]1Cc2ccccc2[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Smac-derived peptide
Synonyms:
SM5F
Type:
fluorescently labelled peptide
Mol. Mass.:
1220.95
Organism:
n/a
Description:
5-carboxyfluorescein was coupled to the lysine side chain of the mutated Smac peptide.
Residue:
10
Sequence:
ARPFKFAMNH