Reaction Details
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AP2-associated protein kinase 1
Ligand
BDBM263005
Substrate
n/a
Meas. Tech.
AAK1 Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
652±n/a nM
Comments
extracted
Citation
Vrudhula, VM; Dzierba, CD; Bronson, JJ; Macor, JE; Nara, SJ; Rajamani, R; Karatholuvhu, MS Aryl amide-based kinase inhibitors US Patent US9708337 Publication Date 7/18/2017 More Info.:
Target
Name:
AP2-associated protein kinase 1
Synonyms:
AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048
Type:
PROTEIN
Mol. Mass.:
103884.23
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774569
Residue:
961
Sequence:
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
Inhibitor
Name:
BDBM263005
Synonyms:
N-(5H-chromeno[3,4-c]pyridin-8-yl)-3-hydroxypropanamide | US9708337, 19
Type:
Small organic molecule
Emp. Form.:
C15H14N2O3
Mol. Mass.:
270.2833
SMILES:
OCCC(=O)Nc1ccc-2c(OCc3cnccc-23)c1
Structure:
