Reaction Details Report a problem with these data
Target
Atypical chemokine receptor 3
Ligand
BDBM385925
Substrate
n/a
Meas. Tech.
Serum Binding Analysis
IC50
1500±n/a nM
Citation
 Fan, J; Krasinski, A; Lange, CW; Lui, RM; McMahon, JP; Powers, JP; Zeng, Y; Zhang, P CXCR7 antagonists US Patent  US10287292 Publication Date 5/14/2019 
Target
Name:
Atypical chemokine receptor 3
Synonyms:
ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1
Type:
Enzyme
Mol. Mass.:
41498.84
Organism:
Homo sapiens (Human)
Description:
P25106
Residue:
362
Sequence:
MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQSTK
  
Inhibitor
Name:
BDBM385925
Synonyms:
US10287292, Compound 1.103 | US11059825, Compound 1.103
Type:
Small organic molecule
Emp. Form.:
C23H23ClN6O
Mol. Mass.:
434.921
SMILES:
Cc1ccn2ccnc(N3CC[C@@H](C3)NC(=O)c3ccn(n3)-c3ccc(Cl)cc3C)c12 |r|
Structure:
Search PDB for entries with ligand similarity: