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Target
Proline-rich AKT1 substrate 1
Ligand
BDBM385993
Substrate
n/a
Meas. Tech.
AKT Enzyme Assay
IC50
62±n/a nM
Citation
 Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent  US10287300 Publication Date 5/14/2019 
Target
Name:
Proline-rich AKT1 substrate 1
Synonyms:
40 kDa proline-rich AKT substrate | AKT1S1 | AKTS1_HUMAN | PRAS40
Type:
PROTEIN
Mol. Mass.:
27368.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_664853
Residue:
256
Sequence:
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQYAKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
  
Inhibitor
Name:
BDBM385993
Synonyms:
2-(1-(2,3-dihydro-1H-pyrrolo[2,3]pyrimidin-4-yl)piperazin-4-yl)-2-(4-(trifluoro-methyl)phenyl)ethanamine | US10287300, Compound A2
Type:
Small organic molecule
Emp. Form.:
C19H23F3N6
Mol. Mass.:
392.4213
SMILES:
NCC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(cc1)C(F)(F)F
Structure:
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