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Target
Ribosomal protein S6 kinase beta-1 [T412E]
Ligand
BDBM386053
Substrate
n/a
Meas. Tech.
P70S6K Enzyme Assay
IC50
>1000±n/a nM
Citation
 Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent  US10287300 Publication Date 5/14/2019 
Target
Name:
Ribosomal protein S6 kinase beta-1 [T412E]
Synonyms:
KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59166.89
Organism:
Homo sapiens (Human)
Description:
P23443[T412E]
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM386053
Synonyms:
4-(4-(1-(3-chloro-4-fluorophenyl)-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)-7,8-dihydropteridin-6(5H)-one | US10287300, Compound A56 | US10287300, Compound A57
Type:
Small organic molecule
Emp. Form.:
C22H27ClFN7O
Mol. Mass.:
459.947
SMILES:
Fc1ccc(cc1Cl)C(CN1CCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12
Structure:
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