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Target
Proline-rich AKT1 substrate 1
Ligand
BDBM386053
Substrate
n/a
Meas. Tech.
AKT Enzyme Assay
IC50
>1000±n/a nM
Citation
 Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent  US10287300 Publication Date 5/14/2019 
Target
Name:
Proline-rich AKT1 substrate 1
Synonyms:
40 kDa proline-rich AKT substrate | AKT1S1 | AKTS1_HUMAN | PRAS40
Type:
PROTEIN
Mol. Mass.:
27368.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_664853
Residue:
256
Sequence:
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQYAKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
  
Inhibitor
Name:
BDBM386053
Synonyms:
4-(4-(1-(3-chloro-4-fluorophenyl)-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)-7,8-dihydropteridin-6(5H)-one | US10287300, Compound A56 | US10287300, Compound A57
Type:
Small organic molecule
Emp. Form.:
C22H27ClFN7O
Mol. Mass.:
459.947
SMILES:
Fc1ccc(cc1Cl)C(CN1CCCC1)N1CCN(CC1)c1ncnc2NCC(=O)Nc12
Structure:
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