Reaction Details Report a problem with these data
Target
Fatty acid-binding protein, adipocyte
Ligand
BDBM263071
Substrate
n/a
Meas. Tech.
FABP Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
20.0±n/a nM
Comments
extracted
Citation
 Buettelmann, B; Ceccarelli, SM; Conte, A; Kuehne, H; Kuhn, B; Neidhart, W; Sander, UO; Richter, H Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors US Patent  US9708340 Publication Date 7/18/2017 
Target
Name:
Fatty acid-binding protein, adipocyte
Synonyms:
A-FABP | AFABP | ALBP | Adipocyte lipid-binding protein | FABP4 | FABP4_HUMAN | Fatty acid binding protein adipocyte | Fatty acid-binding protein 4 | Fatty acid-binding protein 4 (FABP4)
Type:
Enzyme
Mol. Mass.:
14719.23
Organism:
Homo sapiens (Human)
Description:
P15090
Residue:
132
Sequence:
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA
  
Inhibitor
Name:
BDBM263071
Synonyms:
US9708340, 64
Type:
Small organic molecule
Emp. Form.:
C18H16ClFN2O4
Mol. Mass.:
378.782
SMILES:
COc1cc(Cl)cc(NC(=O)N2CC[C@@H]2C(O)=O)c1-c1ccc(F)cc1 |r|
Structure:
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