Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM386158
Substrate
n/a
Meas. Tech.
Measurement of Orexin Type 2 Receptor Agonist Activity
EC50
3500±n/a nM
Citation
 Fujimoto, T; Rikimaru, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent  US10287305 Publication Date 5/14/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM386158
Synonyms:
N-(cis-1-acetyl-2-(((cis-3- phenylcyclobutyl)oxy)methyl)-piperidin- 3-yl)methanesulfonamidea | US10287305, Example 114 | US10508083, Example 114 | US11292766, Example 114
Type:
Small organic molecule
Emp. Form.:
C19H28N2O4S
Mol. Mass.:
380.502
SMILES:
CC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1C[C@H](C1)c1ccccc1 |r,wU:18.21,16.16,13.14,7.7,(-.39,-3.24,;.94,-4.01,;.94,-5.55,;2.28,-3.24,;3.61,-4.01,;4.94,-3.24,;4.94,-1.7,;3.61,-.93,;3.61,.61,;4.94,1.38,;6.28,.61,;3.61,2.15,;6.03,2.47,;2.28,-1.7,;.94,-.93,;.94,.61,;-.39,1.38,;-1.88,.98,;-2.28,2.47,;-.79,2.87,;-3.61,3.24,;-3.61,4.78,;-4.94,5.55,;-6.28,4.78,;-6.28,3.24,;-4.94,2.47,)|
Structure:
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