Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM386818
Substrate
n/a
Meas. Tech.
Measurement of Orexin Type 2 Receptor Agonist Activity
EC50
240±n/a nM
Citation
 Fujimoto, T; Rikimaru, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent  US10287305 Publication Date 5/14/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM386818
Synonyms:
N-(cis-1-(cyclopropylcarbonyl)-2- (((4-(pyridin-2- yl)cyclohexyl)oxy)methyl)piperidin- 3-yl)methanesulfonamide | US10287305, Example 251 | US10508083, Example 251 | US11292766, Example 251
Type:
Small organic molecule
Emp. Form.:
C22H33N3O4S
Mol. Mass.:
435.58
SMILES:
CS(=O)(=O)N[C@H]1CCCN([C@H]1COC1CCC(CC1)c1ccccn1)C(=O)C1CC1 |r,wU:10.11,5.4,(6.67,.38,;5.33,1.15,;4.56,2.49,;6.1,2.49,;4,.38,;4,-1.15,;5.33,-1.93,;5.33,-3.47,;4,-4.23,;2.67,-3.47,;2.67,-1.93,;1.33,-1.15,;1.33,.38,;,1.15,;,2.69,;-1.33,3.47,;-2.67,2.69,;-2.67,1.15,;-1.33,.38,;-4,3.47,;-4,5,;-5.33,5.78,;-6.67,5,;-6.67,3.47,;-5.33,2.69,;1.33,-4.23,;1.33,-5.78,;,-3.47,;-.77,-2.13,;-1.54,-3.47,)|
Structure:
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