Target
Orexin receptor type 2
Ligand
BDBM386893
Substrate
n/a
Meas. Tech.
Measurement of Orexin Type 2 Receptor Agonist Activity
EC50
290±n/a nM
Citation
 Fujimoto, TRikimaru, KSugimoto, HMatsumoto, T Substituted piperidine compound and use thereof US Patent  US10287305 Publication Date 5/14/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM386893
Synonyms:
US10287305, Example 344 | US10508083, Example 344 | US11292766, Example 344 | methyl cis-2-(((cis-4-(4- methoxyphenyl)cyclohexyl)oxy)- methyl)-3- ((methylsulfonyl)amino)piperidine- 1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H34N2O6S
Mol. Mass.:
454.58
SMILES:
COC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccc(OC)cc1 |r,wU:20.24,17.17,14.15,8.8,(,-4.23,;1.33,-3.46,;2.67,-4.23,;2.67,-5.77,;4,-3.47,;5.33,-4.24,;6.67,-3.47,;6.67,-1.93,;5.33,-1.15,;5.33,.39,;6.67,1.16,;8,.39,;5.9,2.49,;7.44,2.49,;4,-1.93,;2.67,-1.16,;2.67,.38,;1.33,1.15,;,.39,;-1.33,1.15,;-1.33,2.69,;,3.46,;1.33,2.69,;-2.67,3.46,;-2.67,5,;-4,5.77,;-5.33,5,;-6.67,5.77,;-8,5,;-5.33,3.46,;-4,2.69,)|
Structure:
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