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Target
Aurora kinase A
Ligand
BDBM26313
Substrate
FAM-PKAtide
Meas. Tech.
Aurora Kinase Assay
pH
7.2±n/a
Temperature
294.15±n/a K
IC50
1200±n/a nM
Citation
 Oslob, JD; Romanowski, MJ; Allen, DA; Baskaran, S; Bui, M; Elling, RA; Flanagan, WM; Fung, AD; Hanan, EJ; Harris, S; Heumann, SA; Hoch, U; Jacobs, JW; Lam, J; Lawrence, CE; McDowell, RS; Nannini, MA; Shen, W; Silverman, JA; Sopko, MM; Tangonan, BT; Teague, J; Yoburn, JC; Yu, CH; Zhong, M; Zimmerman, KM; O'Brien, T; Lew, W Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett 18:4880-4 (2008) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AURKA_MOUSE | Aik | Airk1 | Ark1 | Aura | Aurka | Aurora Kinase A (Aurora-A) | Aurora kinase A | Aurora-family kinase 1 | Aurora/IPL1-related kinase 1 | Ayk1 | Btak | Iak1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Aurora-A | Serine/threonine-protein kinase Ayk1 | Stk15 | Stk6
Type:
Enzyme
Mol. Mass.:
44791.66
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
395
Sequence:
MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQKLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS
  
Inhibitor
Name:
BDBM26313
Synonyms:
3-[1-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1H-imidazol-4-yl]-1-[3-(trifluoromethyl)phenyl]urea | thieno[3,2-d]pyrimidine analogue, 8
Type:
Small organic molecule
Emp. Form.:
C19H16F3N7OS
Mol. Mass.:
447.437
SMILES:
FC(F)(F)c1cccc(NC(=O)Nc2cn(CCNc3ncnc4ccsc34)cn2)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FAM-PKAtide
Synonyms:
n/a
Type:
fluorescien-labeled peptide
Mol. Mass.:
1620.33
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
FAMGRTGRRNSINH