Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM263078
Substrate
n/a
Meas. Tech.
Norovirus Polymerase Inhibition Assay
EC50
3150±n/a nM
Citation
 Bougher, III, JH; Changalvala, RV; Downey, AL; Drach, JC; Lanier, Jr., ER; McIver, AL; Robertson, BD; Selleseth, DW; Sethna, PB; Townsend, L; Ware, RW Pyrrolopyrimidine nucleosides and analogs thereof US Patent  US9708359 Publication Date 7/18/2017 
Target
Name:
Genome polyprotein
Synonyms:
Norovirus Polymerase
Type:
n/a
Mol. Mass.:
187250.43
Organism:
Murine norovirus 1
Description:
Q80J95
Residue:
1685
Sequence:
MRMATPSSAPSVRNTEKRKNKKASSKASVSFGAPSPLSSESEDEINYMTPPEQEAQPGALAALHAEGPLAGLPVTRSDARVLIFNEWEERKKSDPWLRLDMSDKAIFRRYPHLRPKEDRPDAPSHAEDAMDAKEPVIGSILEQDDHKFYHYSVYIGGGLVMGVNNPSAAVCQATIDVEKLHLWWRPVWEPRPLDSAELRKCVGMTVPYVATTVNCYQVCCWIVGIKDTWLKRAKISRDLPFYSPVQDWNVDPQEPFIPSKLRMVSDGILVALSAVIGRPIKNLLASVKPLNILNIVLSCDWTFSGIVNALILLAELFDIFWTPPDVTNWMISIFGEWQAEGPFDLALDVVPTLLGGIGMAFGLTSETIGRKLASTNSALKAAQEMGKFAIEVFKQIMAWIWPSEDPVPALLSNMEQAIIKNECQLENQLTAMLRDRNAGAEFLRSLDEEEQEVRKIAAKCGNSATTGTTNALLARISMARAAFEKARAEQTSRVRPVVIMVSGRPGIGKTCFCQNLAKRIAASLGDETSVGIIPRADVDHWDAYKGARVVLWDDFGMDNVVKDALRLQMLADTCPVTLNCDRIENKGKMFDSQVIIITTNQQTPVPLDYVNLEAVCRRIDFLVYAESPVVDDARARAPGDVNAVKAAMRPDYSHINFILAPQGGFDRQGNTPYGKGVTKIIGATALCARAVALVHERHDDFGLQNKVYDFDAGKVTAFKAMAADAGIPWYKMAAIGCKAMGCTCVEEAMHLLKDYEVAPCQVIYNGATYNVSCIKGAPMVEKVKEPELPKTLVNCVRRIKEARLRCYCRMAADVITSILQAAGTAFSIYHQIEKRSRPSFYWDGYTYRDGPGSFDIFEDDDDGWYHSEGKKGKNKKGRGRPGVFRTRGLTDEEYDEFKKRRESRGGKYSIDDYLADREREEELLERDEEEAIFGDGFGLKATRRSRKAERAKLGLVSGGDIRARKPIDWNVVGPSWADDDRQVDYGEKINFEAPVSIWSRVVQFGTGWGFWVSGHVFITAKHVAPPKGTEIFGRKPGDFTVTSSGDFLKYYFTSAVRPDIPAMVLENGCQEGVVASVLVKRASGEMLALAVRMGSQAAIKIGSAVVHGQTGMLLTGSNAKAQDLGTIPGDCGCPYVYKKGNTWVVIGVHVAATRSGNTVIAATHGEPTLEALEFQGPPMLPRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCPCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLELDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGEKYYRTVASRVSKEAAQSGIEMVVPRHRSVLRWVRFGTMDAETPQERSAVFVNEDE
  
Inhibitor
Name:
BDBM263078
Synonyms:
US9708359, 71
Type:
Small organic molecule
Emp. Form.:
C13H18N5O8P
Mol. Mass.:
403.2845
SMILES:
Cc1nc(N)c2c(cn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: