Target
Genome polyprotein
Ligand
BDBM263104
Substrate
n/a
Meas. Tech.
Norovirus Polymerase Inhibition Assay
EC50
>100000±n/a nM
Citation
 Bougher, III, JHChangalvala, RVDowney, ALDrach, JCLanier, Jr., ERMcIver, ALRobertson, BDSelleseth, DWSethna, PBTownsend, LWare, RW Pyrrolopyrimidine nucleosides and analogs thereof US Patent  US9708359 Publication Date 7/18/2017 
Target
Name:
Genome polyprotein
Synonyms:
Norovirus Polymerase
Type:
n/a
Mol. Mass.:
187250.43
Organism:
Murine norovirus 1
Description:
Q80J95
Residue:
1685
Sequence:
MRMATPSSAPSVRNTEKRKNKKASSKASVSFGAPSPLSSESEDEINYMTPPEQEAQPGALAALHAEGPLAGLPVTRSDARVLIFNEWEERKKSDPWLRLDMSDKAIFRRYPHLRPKEDRPDAPSHAEDAMDAKEPVIGSILEQDDHKFYHYSVYIGGGLVMGVNNPSAAVCQATIDVEKLHLWWRPVWEPRPLDSAELRKCVGMTVPYVATTVNCYQVCCWIVGIKDTWLKRAKISRDLPFYSPVQDWNVDPQEPFIPSKLRMVSDGILVALSAVIGRPIKNLLASVKPLNILNIVLSCDWTFSGIVNALILLAELFDIFWTPPDVTNWMISIFGEWQAEGPFDLALDVVPTLLGGIGMAFGLTSETIGRKLASTNSALKAAQEMGKFAIEVFKQIMAWIWPSEDPVPALLSNMEQAIIKNECQLENQLTAMLRDRNAGAEFLRSLDEEEQEVRKIAAKCGNSATTGTTNALLARISMARAAFEKARAEQTSRVRPVVIMVSGRPGIGKTCFCQNLAKRIAASLGDETSVGIIPRADVDHWDAYKGARVVLWDDFGMDNVVKDALRLQMLADTCPVTLNCDRIENKGKMFDSQVIIITTNQQTPVPLDYVNLEAVCRRIDFLVYAESPVVDDARARAPGDVNAVKAAMRPDYSHINFILAPQGGFDRQGNTPYGKGVTKIIGATALCARAVALVHERHDDFGLQNKVYDFDAGKVTAFKAMAADAGIPWYKMAAIGCKAMGCTCVEEAMHLLKDYEVAPCQVIYNGATYNVSCIKGAPMVEKVKEPELPKTLVNCVRRIKEARLRCYCRMAADVITSILQAAGTAFSIYHQIEKRSRPSFYWDGYTYRDGPGSFDIFEDDDDGWYHSEGKKGKNKKGRGRPGVFRTRGLTDEEYDEFKKRRESRGGKYSIDDYLADREREEELLERDEEEAIFGDGFGLKATRRSRKAERAKLGLVSGGDIRARKPIDWNVVGPSWADDDRQVDYGEKINFEAPVSIWSRVVQFGTGWGFWVSGHVFITAKHVAPPKGTEIFGRKPGDFTVTSSGDFLKYYFTSAVRPDIPAMVLENGCQEGVVASVLVKRASGEMLALAVRMGSQAAIKIGSAVVHGQTGMLLTGSNAKAQDLGTIPGDCGCPYVYKKGNTWVVIGVHVAATRSGNTVIAATHGEPTLEALEFQGPPMLPRPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCPCTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLELDMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGEKYYRTVASRVSKEAAQSGIEMVVPRHRSVLRWVRFGTMDAETPQERSAVFVNEDE
  
Inhibitor
Name:
BDBM263104
Synonyms:
US9708359, 29
Type:
Small organic molecule
Emp. Form.:
C13H13ClN4O4
Mol. Mass.:
324.72
SMILES:
Cc1nc(Cl)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C#N |r|
Structure:
Search PDB for entries with ligand similarity: