Reaction Details Report a problem with these data
Target
Glutaminase kidney isoform, mitochondrial [63-669]
Ligand
BDBM387015
Substrate
n/a
Meas. Tech.
Enzyme Potency Assay
IC50
95.2±n/a nM
Citation
 Nissink, JW; Finlay, MR; Charles, MD; Wood, M 1,3,4-thiadiazole compounds and their use in treating cancer US Patent  US9938265 Publication Date 4/10/2018 
Target
Name:
Glutaminase kidney isoform, mitochondrial [63-669]
Synonyms:
GLS | GLS1 | GLSK_HUMAN | Glutaminase kidney isoform, mitochondrial (aa 63-669) | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase
Type:
n/a
Mol. Mass.:
66963.68
Organism:
Homo sapiens (Human)
Description:
O94925 aa 63-669
Residue:
607
Sequence:
WPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
  
Inhibitor
Name:
BDBM387015
Synonyms:
(2S)-2-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide and (2R)-2-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide | US9938265, Example 7(a)
Type:
Small organic molecule
Emp. Form.:
C21H22F3N7O3S
Mol. Mass.:
509.505
SMILES:
CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC(F)(F)F)c1 |r|
Structure:
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