Reaction Details Report a problem with these data
Target
Glutaminase kidney isoform, mitochondrial [63-669]
Ligand
BDBM387030
Substrate
n/a
Meas. Tech.
Enzyme Potency Assay
IC50
24.3±n/a nM
Citation
 Nissink, JW; Finlay, MR; Charles, MD; Wood, M 1,3,4-thiadiazole compounds and their use in treating cancer US Patent  US9938265 Publication Date 4/10/2018 
Target
Name:
Glutaminase kidney isoform, mitochondrial [63-669]
Synonyms:
GLS | GLS1 | GLSK_HUMAN | Glutaminase kidney isoform, mitochondrial (aa 63-669) | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase
Type:
n/a
Mol. Mass.:
66963.68
Organism:
Homo sapiens (Human)
Description:
O94925 aa 63-669
Residue:
607
Sequence:
WPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
  
Inhibitor
Name:
BDBM387030
Synonyms:
N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-methoxy-2[3-(trifluoromethoxy)phenyl]acetamide | US9938265, Example 17 | US9938265, Example 18
Type:
Small organic molecule
Emp. Form.:
C20H19F4N7O3S
Mol. Mass.:
513.469
SMILES:
COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(OC(F)(F)F)c1
Structure:
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