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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM387101
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
10000±n/a nM
Citation
 Kim, RM; Kuduk, SD; Liverton, N; Zhou, G 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists US Patent  US9938276 Publication Date 4/10/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM387101
Synonyms:
2-(cis-6-(2-(2H-1,2,3-triazol-2- yl)benzoyl)ocathydro-1H-pyrrolo[2,3- c]pyridin-1-yl)-3-methylisonicotinonitrile | US9938276, A15
Type:
Small organic molecule
Emp. Form.:
C22H20ClN7O
Mol. Mass.:
433.894
SMILES:
Clc1cc(C#N)c(cn1)N1CC[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1
Structure:
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