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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM387106
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
3964±n/a nM
Citation
 Kim, RM; Kuduk, SD; Liverton, N; Zhou, G 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists US Patent  US9938276 Publication Date 4/10/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM387106
Synonyms:
(3aR, 7aR)-6-{[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}-1-[4- (trifluoromethyl)pyridin-2-yl]octahydro-1H- pyrrolo[2,3-c]pyridine | US9938276, A20
Type:
Small organic molecule
Emp. Form.:
C22H20ClN7O
Mol. Mass.:
433.894
SMILES:
Clc1c(ccnc1N1CC[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1)C#N
Structure:
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