Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM387126
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
948±n/a nM
Citation
 Kim, RM; Kuduk, SD; Liverton, N; Zhou, G 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists US Patent  US9938276 Publication Date 4/10/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM387126
Synonyms:
(3aR, 7aR)-1-(5,6-dimethylpyrazin-2-yl)-6- {[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}octahydro-1H- pyrrolo[2,3-c]pyridine | US9938276, B21
Type:
Small organic molecule
Emp. Form.:
C22H25N7O
Mol. Mass.:
403.4802
SMILES:
Cc1ncc(nc1C)N1CC[C@@H]2CCN(C[C@H]12)C(=O)c1ccccc1-n1nccn1
Structure:
Search PDB for entries with ligand similarity: