Reaction Details Report a problem with these data
Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM26459
Substrate
BDBM26431
Meas. Tech.
MurD Inhibition Assay
IC50
>2000000±n/a nM
Citation
Humljan, J; Kotnik, M; Contreras-Martel, C; Blanot, D; Urleb, U; Dessen, A; Solmajer, T; Gobec, S Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme. J Med Chem 51:7486-94 (2008) [PubMed] Article
More Info.:
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD
Type:
Ligase
Mol. Mass.:
46963.02
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
438
Sequence:
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
Inhibitor
Name:
BDBM26459
Synonyms:
1,5-dimethyl (2R)-2-[(6-butoxynaphthalene-2-)sulfonamido]pentanedioate | naphthylsulfonamide, 16c
Type:
Small organic molecule
Emp. Form.:
C21H27NO7S
Mol. Mass.:
437.507
SMILES:
CCCCOc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H](CCC(=O)OC)C(=O)OC |r|