Reaction Details Report a problem with these data
Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM26463
Substrate
BDBM26431
Meas. Tech.
MurD Inhibition Assay
IC50
>1000000±n/a nM
Citation
 Humljan, J; Kotnik, M; Contreras-Martel, C; Blanot, D; Urleb, U; Dessen, A; Solmajer, T; Gobec, S Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme. J Med Chem 51:7486-94 (2008) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD
Type:
Ligase
Mol. Mass.:
46963.02
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
438
Sequence:
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
  
Inhibitor
Name:
BDBM26463
Synonyms:
(2R)-2-[(6-butoxynaphthalene-2-)(methyl)sulfonamido]pentanedioic acid | naphthylsulfonamide, 31
Type:
Small organic molecule
Emp. Form.:
C20H25NO7S
Mol. Mass.:
423.48
SMILES:
CCCCOc1ccc2cc(ccc2c1)S(=O)(=O)N(C)[C@H](CCC(O)=O)C(O)=O |r|
Structure:
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Substrate
Name:
BDBM26431
Synonyms:
(2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Glu | D-Glutamate | D-[14C]Glu
Type:
radiolabeled amino acid
Emp. Form.:
C5H9NO4
Mol. Mass.:
147.1293
SMILES:
N[C@H](CCC(O)=O)C(O)=O
Structure:
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