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Target
Estrogen receptor [D538G]
Ligand
BDBM50395019
Substrate
n/a
Meas. Tech.
HS-R1a radioreceptor assay
IC50
11200±n/a nM
Citation
 Ong, H; Chemtob, S; Lubell, W; Sennlaub, F; Boeglin, D; Proulx, C; Sajjadi, Z; Sabatino, D Azapeptides as CD36 binding compounds US Patent  US9708370 Publication Date 7/18/2017 
Target
Name:
Estrogen receptor [D538G]
Synonyms:
ESR | ESR1 | ESR1_HUMAN | Estrogen receptor alpha D538G | NR3A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66173.42
Organism:
Homo sapiens (Human)
Description:
P03372[D538G]
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYGLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50395019
Synonyms:
CHEMBL2163449 | US9708370, CP-2B(v)
Type:
Small organic molecule
Emp. Form.:
C45H59N11O6
Mol. Mass.:
850.0201
SMILES:
CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O |r|
Structure:
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