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TargetMatrix metalloproteinase-7 (MMP7)
LigandBDBM26567
Substrate/CompetitorMMP Substrate Peptide
Meas. Tech.Enzyme Inhibition Assay
Ki 811±n/a nM
Citation Lu, ZOtt, GRAnand, RLiu, RQCovington, MBVaddi, KQian, MNewton, RCChrist, DDTrzaskos, JDuan, JJ Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents. Bioorg Med Chem Lett18:1958-62 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Matrix metalloproteinase-7 (MMP7)
Name:Matrix metalloproteinase 7
Synonyms:Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7)
Type:Enzyme
Mol. Mass.:29681.54
Organism:Homo sapiens (Human)
Description:P09237
Residue:267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD
PQNFKLSQDDIKGIQKLYGKRSNSRKK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM26567
NameBDBM26567
Synonyms:(3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)-1-benzofuran-3-yl]methyl}benzene)oxane-3,4-dicarboxamide | 2-isopropylbenzofuran, 28
TypeSmall organic molecule
Emp. Form.C25H28N2O5
Mol. Mass.436.5002
SMILESCC(C)c1oc2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
MMP Substrate Peptide
Name:MMP Substrate Peptide
Synonyms:n/a
Type:Fluorogenic Peptide
Mol. Mass.:2468.31
Organism:n/a
Description:MCA, (7-methoxycoumarin-4-yl)acetyl. Dpa, N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl.
Residue:23
Sequence:
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2