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Target
Interleukin-2
Ligand
BDBM387274
Substrate
n/a
Meas. Tech.
Inhibition of IL-2 secretion
IC50
<100.0±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019 
Target
Name:
Interleukin-2
Synonyms:
IL-2 | IL2 | IL2_HUMAN | INN=Aldesleukin | Interleukin-2 | Interleukin-2 (IL-2) | T-cell growth factor | TCGF
Type:
Enzyme
Mol. Mass.:
17630.05
Organism:
Homo sapiens (Human)
Description:
P60568
Residue:
153
Sequence:
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
  
Inhibitor
Name:
BDBM387274
Synonyms:
N-(2,6- Difluorophenyl)-5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol- 3-yl)-2-ethyl- phenyl)thiophene- 2-carboxamide | US10292981, Example 157
Type:
Small organic molecule
Emp. Form.:
C24H20F2N2O3S
Mol. Mass.:
454.489
SMILES:
CCc1ccc(cc1-c1ccc(s1)C(=O)Nc1c(F)cccc1F)C1=NOC(C)(C)C1=O |t:27|
Structure:
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