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Target
Nuclear factor of activated T-cells, cytoplasmic 2
Ligand
BDBM387273
Substrate
n/a
Meas. Tech.
NFAT Transcriptional Activity
IC50
<500±n/a nM
Citation
 Irlapati, NR; Deshmukh, GK; Karche, VP; Jachak, SM; Sinha, N; Palle, VP; Kamboj, RK Oxazoline and isoxazoline derivatives as CRAC modulators US Patent  US10292981 Publication Date 5/21/2019 
Target
Name:
Nuclear factor of activated T-cells, cytoplasmic 2
Synonyms:
NF-ATc2 | NF-ATp | NFAC2_HUMAN | NFAT pre-existing subunit | NFAT1 | NFATC2 | NFATP | T-cell transcription factor NFAT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
100156.24
Organism:
Homo sapiens (Human)
Description:
Q13469
Residue:
925
Sequence:
MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDVNEIIRKEFSGPPARNQT
  
Inhibitor
Name:
BDBM387273
Synonyms:
US10292981, Example 135
Type:
Small organic molecule
Emp. Form.:
C25H21F2N3O3
Mol. Mass.:
449.4493
SMILES:
CNc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O |t:28|
Structure:
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