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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM26634
Substrate
S6 kinase/Rsk-2 peptide 2
Meas. Tech.
Pim Kinase Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
650±50 nM
Citation
 Xia, Z; Knaak, C; Ma, J; Beharry, ZM; McInnes, C; Wang, W; Kraft, AS; Smith, CD Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem 52:74-86 (2009) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM26634
Synonyms:
(5Z)-5-[(3-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione | thiazolidine-2,4-dione, 12a
Type:
Small organic molecule
Emp. Form.:
C11H9NO3S
Mol. Mass.:
235.259
SMILES:
COc1cccc(C=C2SC(O)=NC2=O)c1 |w:7.6,c:11|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
S6 kinase/Rsk-2 peptide 2
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1149.41
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
KKRNRTLTK