Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM387769
Substrate
n/a
Meas. Tech.
LANCE Assay
EC50
501±n/a nM
Citation
 Cone, RD; Bishop, MJ; Stewart, EL; Wolfe, LA; Pantel, J; Sebag, J; Weaver, CD; Williams, S; Cox, H; Tough, I; Gimenez, LD; Baskaran, S Positive allosteric modulators of human melanocortin-4 receptor US Patent  US10294214 Publication Date 5/21/2019 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM387769
Synonyms:
US10294214, Example 69
Type:
Small organic molecule
Emp. Form.:
C29H33N4O3
Mol. Mass.:
485.5973
SMILES:
O=C(CN1CCC(CC1)c1ccccc1)Nc1c(nc2ccc(cc12)N1CCOCC1)C(=O)C1CC1
Structure:
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