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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM26695
Substrate
Calf Thymus Histone
Meas. Tech.
Radioactive Filter Plate Assay
pH
7.5±n/a
Temperature
296.15±n/a K
IC50
>20000±n/a nM
Citation
 Cheney, IW; Yan, S; Appleby, T; Walker, H; Vo, T; Yao, N; Hamatake, R; Hong, Z; Wu, JZ Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett 17:1679-83 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM26695
Synonyms:
4-oxo-6-(pyridin-4-yl)-3-azatricyclo[8.4.0.0^{2,7}]tetradeca-1(10),2(7),5,11,13-pentaene-5-carbonitrile | pyridone-based compound, 23
Type:
Small organic molecule
Emp. Form.:
C19H13N3O
Mol. Mass.:
299.326
SMILES:
O=c1[nH]c-2c(CCc3ccccc-23)c(-c2ccncc2)c1C#N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Calf Thymus Histone
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
358.43
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
3
Sequence:
NA