Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1 [30-579]
Ligand
BDBM26724
Substrate
BDBM22988
Meas. Tech.
FAAH Carbon Filtration Assay
pH
8±n/a
Temperature
295.15±n/a K
IC50
21±6 nM
Citation
 Wang, X; Sarris, K; Kage, K; Zhang, D; Brown, SP; Kolasa, T; Surowy, C; El Kouhen, OF; Muchmore, SW; Brioni, JD; Stewart, AO Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. J Med Chem 52:170-80 (2009) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [30-579]
Synonyms:
Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:
Single-pass membrane protein; homodimer
Mol. Mass.:
60474.00
Organism:
Rattus norvegicus (rat)
Description:
P97612 (aa 30-579)
Residue:
550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
  
Inhibitor
Name:
BDBM26724
Synonyms:
N-[4-(quinolin-2-yl)phenyl]-1-(thiophene-2-sulfonyl)piperidine-4-carboxamide | quinoline analogue, 16e
Type:
Small organic molecule
Emp. Form.:
C25H23N3O3S2
Mol. Mass.:
477.598
SMILES:
O=C(Nc1ccc(cc1)-c1ccc2ccccc2n1)C1CCN(CC1)S(=O)(=O)c1cccs1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22988
Synonyms:
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide | AEA | ANANDAMIDE | Arachidonoyl ethanolamide | Arachidonoyl ethanolamide (AEA) | Arachidonoylethanolamide (AEA) | Arachidonylethanolamide | CHEMBL15848 | [14C]Anandamide | [3H]Anandamide
Type:
radiolabeled substrate
Emp. Form.:
C22H37NO2
Mol. Mass.:
347.5347
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO
Structure:
Search PDB for entries with ligand similarity: