Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1
Ligand
BDBM26741
Substrate
BDBM23028
Meas. Tech.
FAAH Inhibition Assay (30 min Preincubation)
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
473±n/a nM
Comments
time-dependent inhibition.
Citation
Ahn, K; Johnson, DS; Fitzgerald, LR; Liimatta, M; Arendse, A; Stevenson, T; Lund, ET; Nugent, RA; Nomanbhoy, TK; Alexander, JP; Cravatt, BF Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46:13019-30 (2007) [PubMed] Article
More Info.:
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
Inhibitor
Name:
BDBM26741
Synonyms:
N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide | PF-622 | US9169224, 19
Type:
Small organic molecule
Emp. Form.:
C21H22N4O
Mol. Mass.:
346.4256
SMILES:
O=C(Nc1ccccc1)N1CCN(Cc2ccc3ccccc3n2)CC1