Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM387782
Substrate
n/a
Meas. Tech.
Determination of Allosteric Potency EC50 Values for Muscarinic M1 Receptor
EC50
681±n/a nM
Citation
 Nirogi, R; Shinde, AK; Mohammed, AR; Subramanian, R; Benade, VS; Bhyrapuneni, G; Jasti, V Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators US Patent  US10294217 Publication Date 5/21/2019 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM387782
Synonyms:
N-[(1S,2S)-2-Hydroxycyclohexyl]-1-(2-chloropyridin-4-ylmethyl)-4-fluoro-1H-indole-3-carboxamide | US10294217, Example 2
Type:
Small organic molecule
Emp. Form.:
C21H21ClFN3O2
Mol. Mass.:
401.862
SMILES:
O[C@H]1CCCC[C@@H]1NC(=O)c1cn(Cc2ccnc(Cl)c2)c2cccc(F)c12 |r|
Structure:
Search PDB for entries with ligand similarity: