Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM387795
Substrate
n/a
Meas. Tech.
Determination of Allosteric Potency EC50 Values for Muscarinic M1 Receptor
EC50
1441±n/a nM
Citation
 Nirogi, R; Shinde, AK; Mohammed, AR; Subramanian, R; Benade, VS; Bhyrapuneni, G; Jasti, V Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators US Patent  US10294217 Publication Date 5/21/2019 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM387795
Synonyms:
Cis-N-(3-Fluoropiperidin-4-yl)-1-(2-fluoropyridin-4-ylmethyl)-4,7-difluoro-1H-indole-3-carboxamide hydrochloride (Isomer-I) | US10294217, Example 22 | US10294217, Example 23 | US10294217, Example 24 | US10294217, Example 25
Type:
Small organic molecule
Emp. Form.:
C20H18F4N4O
Mol. Mass.:
406.3767
SMILES:
FC1CNCCC1NC(=O)c1cn(Cc2ccnc(F)c2)c2c(F)ccc(F)c12
Structure:
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