Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM388185
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
IC50
2.00±n/a nM
Citation
 Gardner, DSSantella, JBPaidi, VRWu, HDuncia, JVNair, SKHynes, JZhu, X Heteroaryl substituted aminopyridine compounds US Patent  US10294229 Publication Date 5/21/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM388185
Synonyms:
1-(4-(isopropylamino)-5-(4-(piperidin-4-yl)-1H-1,2,3-triazol-1-yl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile, 2 HCl | US10294229, Example 334
Type:
Small organic molecule
Emp. Form.:
C22H24N10
Mol. Mass.:
428.493
SMILES:
CC(C)Nc1cc(ncc1-n1cc(nn1)C1CCNCC1)-n1ncc2cc(cnc12)C#N
Structure:
Search PDB for entries with ligand similarity: