Target
Proteasome subunit beta type-8
Ligand
BDBM388385
Substrate
n/a
Meas. Tech.
Determination of LMP7 Activity
IC50
<50±n/a nM
Citation
 Klein, MSchadt, OHaselmayer, PBusch, M Substituted boronic acids and boronate esters as immunoproteasome inhibitors US Patent  US10294246 Publication Date 5/21/2019 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM388385
Synonyms:
US10294246, Compound No. 82
Type:
Small organic molecule
Emp. Form.:
C20H22BNO5
Mol. Mass.:
367.203
SMILES:
COc1ccc(CC(=O)N[C@@H](Cc2coc3c(C)cccc23)B(O)O)cc1 |r|
Structure:
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