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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM388457
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
98.0±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Donofrio, A; Fischmann, T; Gibeau, CR; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF; Torres, L Inhibitors of IRAK4 activity US Patent  US9943516 Publication Date 4/17/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM388457
Synonyms:
4-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino] quinazolin-6-yl} cyclohexanecarboxylic acid | US9943516, 3-6
Type:
Small organic molecule
Emp. Form.:
C25H34N4O3
Mol. Mass.:
438.5625
SMILES:
OC(=O)C1CCC(CC1)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:21.25,wD:18.18,(-9.33,-.38,;-8,.39,;-8,1.93,;-6.66,-.38,;-5.33,.39,;-4,-.38,;-4,-1.92,;-5.33,-2.69,;-6.66,-1.92,;-2.66,-2.69,;-2.66,-4.23,;-1.33,-5,;0,-4.23,;1.34,-5,;2.67,-4.23,;2.67,-2.69,;1.34,-1.92,;1.34,-.38,;2.67,.39,;4,-.38,;5.33,.39,;5.33,1.92,;4,2.69,;2.67,1.92,;6.66,2.69,;8,1.92,;9.33,2.69,;9.33,4.23,;8,5,;6.66,4.23,;0,-2.69,;-1.33,-1.92,)|
Structure:
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