Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor
Ligand
BDBM388770
Substrate
n/a
Meas. Tech.
In Vitro c-Met Kinase Enzyme Assay
IC50
<500±n/a nM
Citation
 Zhuo, J; Xu, M; He, C; Zhang, C; Qian, D; Burns, DM; Li, Y; Metcalf, B; Yao, W Imidazotriazines and imidazopyrimidines as kinase inhibitors US Patent  US9944645 Publication Date 4/17/2018 
Target
Name:
Hepatocyte growth factor receptor
Synonyms:
Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase
Type:
Protein
Mol. Mass.:
155559.73
Organism:
Homo sapiens (Human)
Description:
P08581
Residue:
1390
Sequence:
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM388770
Synonyms:
2-Fluoro-N-(trans-4-hydroxycyclohexyl)-4-[7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide | US10738052, Example 100 | US11261191, Example 100 | US9944645, 100
Type:
Small organic molecule
Emp. Form.:
C30H27FN6O2
Mol. Mass.:
522.5728
SMILES:
O[C@H]1CC[C@@H](CC1)NC(=O)c1ccc(cc1F)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1 |r,wU:4.7,wD:1.0,(-12.11,1.15,;-10.72,1.15,;-9.95,-.18,;-8.41,-.18,;-7.64,1.15,;-8.41,2.49,;-9.95,2.49,;-6.1,1.15,;-4.77,1.93,;-4.77,3.47,;-3.44,1.15,;-2.1,1.93,;-.77,1.15,;-.77,-.39,;-2.1,-1.15,;-3.44,-.39,;-4.54,-1.03,;.56,-1.15,;.56,-2.69,;1.9,-3.47,;3.23,-2.69,;4.7,-3.17,;5.6,-1.93,;4.7,-.68,;3.23,-1.15,;1.9,-.39,;5.47,.65,;5.47,2.19,;4.13,1.42,;6.78,.65,;6.78,-.89,;8.11,-1.66,;9.44,-.89,;10.78,-1.66,;12.11,-.89,;12.11,.65,;10.78,1.42,;9.44,.65,;8.11,1.42,)|
Structure:
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