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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM309529
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
210±n/a nM
Citation
 Crosignani, S; Cauwenberghs, S; Driessens, G; Deroose, F Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors US Patent  US9949951 Publication Date 4/24/2018 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM309529
Synonyms:
3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione | US10945994, Compound 1 | US9603836, Compound 1 | US9603836, Compound 1a | US9949951, 1a
Type:
Small organic molecule
Emp. Form.:
C12H9FN2O2
Mol. Mass.:
232.2105
SMILES:
Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
Structure:
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